Neurons are nature’s solution to fast, adaptive and reliable information processing. At the Neuroengineering and Computational Neuroscience Lab, we study how neural circuits encode, transmit, store and transform information — and how this knowledge can be used to develop new technologies to monitor, interpret and repair neural function.

We are a multidisciplinary research group at i3S, integrating neuroscience, engineering, computation and clinical neurotechnology. Our work combines microelectrode arrays, microfluidics, functional imaging, human iPSC-derived neuronal cultures, organotypic preparations, computational modelling, machine learning and neuro-electronic interfaces. This combination allows us to study neuronal population dynamics under highly controlled conditions and to develop strategies for closed-loop modulation of neural activity. The official i3S description of the group highlights this combined focus on neural computation, electrophysiology, functional imaging, microfluidics, machine learning and neuroengineering.

Our research spans both fundamental neurobiology and technological innovation. In vitro and ex vivo platforms allow us to monitor and perturb neuronal activity with high spatiotemporal precision, while collaborations with clinicians enable translational work using electrophysiological recordings from patients with neurological disease, including epilepsy and Parkinson’s disease. A long-term goal of the lab is to create neurotechnologies and computational tools for therapies based on the real-time decoding and control of neural electrophysiology — from engineered neural circuits to adaptive neuromodulation.